A Post - Vaccination Autoinflammatory Syndrome Authors

The current massive vaccination brings a Janusfaced problem. There is a need to assess a positive effect but also to anticipate the abnormal immune response. Repeated administration of aluminum containing vaccines represents a possible risk factor for different aberrant reactions including the autoinflammatory syndrome that at this stage can be called enigmatic postvaccination phenomena. Described case gave rise to the suggestion that vaccination could cause the undesired and unintentional hyper activation of the inflammatory system due to lymph node hyperplasia. Castleman like disease is presented as autoinflammatory syndrome. The dysfunction in the immune/inflammatory response seems to play an etiologic role and leads to a high degree of systemic, sterile inflammation. A temporal relationship between vaccination and the adverse reactions, latency period, can involve weeks and months. Autoinflammatory disease is interesting by severe chronic anemia of inflammation and with decreased levels in serum lipid profile. The extirpation of localized lymphoid tumor in the abdomen was beneficial to the patient and immediately ended-up the inflammatory state and normalized the abnormal laboratory results. Studies addressing this issue are limited.